Johanna Myllyharju Selected Research

3,4-dehydroproline

12/2004

Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1alpha-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for the proline leads to a high rate of uncoupled 2-oxoglutarate decarboxylation.

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Johanna Myllyharju Research Topics

Disease

41	Hypoxia (Hypoxemia) 01/2022 - 06/2002
7	Inflammation (Inflammations) 01/2022 - 01/2009
4	Insulin Resistance 01/2022 - 10/2014
4	Neoplasms (Cancer) 10/2017 - 02/2007
4	Anemia 04/2016 - 01/2008
3	Ischemia 01/2022 - 04/2010
3	Stroke (Strokes) 01/2022 - 01/2008
3	Atherosclerotic Plaque (Atheroma) 01/2021 - 02/2009
2	Fibrosis (Cirrhosis) 10/2017 - 01/2016
2	Polycythemia (Erythrocytosis) 01/2017 - 01/2016
2	Neoplasm Metastasis (Metastasis) 01/2017 - 04/2013
2	Atherosclerosis 04/2016 - 02/2009
2	Obesity 04/2016 - 10/2014
2	Myocardial Infarction 01/2009 - 01/2008
2	Peripheral Vascular Diseases (Peripheral Vascular Disease) 01/2009 - 01/2008
1	Alopecia (Baldness) 01/2022
1	Neuroinflammatory Diseases 01/2022
1	Body Weight (Weight, Body) 01/2022
1	Cysts 01/2022
1	Hyperglycemia 01/2022
1	Hypertrophy 01/2022
1	Metabolic Diseases (Metabolic Disease) 12/2020
1	Non-alcoholic Fatty Liver Disease 01/2020
1	Wounds and Injuries (Trauma) 01/2020
1	Fatty Liver 01/2019
1	Alcoholic Fatty Liver 01/2019
1	Inborn Genetic Diseases (Disease, Hereditary) 10/2017
1	Weight Gain 04/2016
1	Sclerosis 01/2016
1	Albuminuria 01/2016
1	Colorectal Neoplasms (Colorectal Cancer) 10/2015
1	Kidney Diseases (Kidney Disease) 04/2013
1	Carcinogenesis 04/2013
1	Pathologic Processes 04/2013
1	Myopia 09/2011
1	Breast Neoplasms (Breast Cancer) 07/2011
1	Genomic Instability 06/2011
1	Infarction (Infarctions) 04/2010
1	Hypersensitivity (Allergy) 01/2009
1	Osteogenesis Imperfecta (Lobstein Disease) 07/2008
1	Starvation 03/2008
1	Cicatrix (Scar) 01/2008

Drug/Important Bio-Agent (IBA)

23	Oxygen (Dioxygen)IBA 01/2022 - 08/2003
14	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 01/2022 - 10/2007
14	CollagenIBA 01/2021 - 06/2002
12	Transcription Factors (Transcription Factor)IBA 04/2013 - 06/2002
6	EnzymesIBA 10/2019 - 03/2004
6	Peptides (Polypeptides)IBA 07/2008 - 06/2002
5	IsoenzymesIBA 01/2022 - 10/2012
5	Glucose (Dextrose)FDA LinkGeneric 04/2016 - 01/2009
4	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2005
4	Proline (L-Proline)FDA Link 12/2020 - 06/2002
4	Mixed Function Oxygenases (Monooxygenases)IBA 01/2017 - 08/2005
3	CholesterolIBA 01/2022 - 04/2016
3	Messenger RNA (mRNA)IBA 01/2022 - 10/2012
3	Erythropoietin FDA Link 09/2020 - 01/2016
3	IronIBA 04/2013 - 01/2009
2	Small Interfering RNA (siRNA)IBA 01/2022 - 10/2007
2	ChromatinIBA 09/2020 - 06/2011
2	Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA 01/2017 - 07/2011
2	LipidsIBA 04/2016 - 01/2016
2	Pharmaceutical PreparationsIBA 04/2013 - 01/2009
2	disodium salt olean-11,13(18)-diene-3,30-diol dihemiphthalateIBA 10/2007 - 09/2006
1	Keratins (Keratin)IBA 01/2022
1	Leucine (L-Leucine)FDA Link 01/2022
1	Triglycerides (Triacylglycerol)IBA 01/2022
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2022
1	Protein Isoforms (Isoforms)IBA 09/2020
1	Methionine (L-Methionine)FDA Link 01/2020
1	FructoseIBA 01/2020
1	Choline (Choline Chloride)IBA 01/2020
1	Biological ProductsIBA 10/2019
1	Lipoproteins (Lipoprotein)IBA 01/2019
1	Ethanol (Ethyl Alcohol)IBA 01/2019
1	AntioxidantsIBA 01/2019
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2018
1	Collagen Type I (Type I Collagen)IBA 10/2017
1	CopperIBA 04/2016
1	LDL Lipoproteins (beta Lipoproteins)IBA 04/2016
1	oxidized low density lipoproteinIBA 04/2016
1	LDL Receptors (LDL Receptor)IBA 04/2016
1	FG-4497IBA 04/2016
1	AutoantibodiesIBA 04/2016
1	GlycogenIBA 03/2016
1	Adenosine Diphosphate (ADP)IBA 03/2016
1	PhosphofructokinasesIBA 03/2016
1	Adenosine Triphosphate (ATP)IBA 03/2016
1	2-oxoglutarate 3-dioxygenase prolineIBA 09/2011
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 07/2011
1	Histones (Histone)IBA 06/2011
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 04/2010
1	Apolipoproteins E (ApoE)IBA 02/2009
1	Peptide Hydrolases (Proteases)FDA Link 02/2009
1	3-hydroxyprolineIBA 07/2008
1	CarbonIBA 03/2008
1	Methanol (Carbinol)IBA 03/2008
1	oxalylglycineIBA 11/2007

Therapy/Procedure

4	Therapeutics 01/2022 - 10/2014
1	Drug Therapy (Chemotherapy) 10/2015
1	Bioreactors (Bioreactor) 03/2008